Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM357273
Substrate
n/a
Meas. Tech.
Human Platelet Aggregation Inhibition Test
IC50
70.0±n/a nM
Citation
 Tran, T; Ibarra, JB; Shin, Y; Ullman, B; Zou, N; Zeng, X Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent  US10214518 Publication Date 2/26/2019 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM357273
Synonyms:
2-(((1s,4s)-4-((5-(2- hydroxyethylthio)-3,4- diphenyl-1H-pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid | US10214518, Compound 146
Type:
Small organic molecule
Emp. Form.:
C27H32N2O4S
Mol. Mass.:
480.619
SMILES:
OCCSc1c(c(nn1C[C@@H]1CC[C@H](COCC(O)=O)CC1)-c1ccccc1)-c1ccccc1 |r,wU:10.10,13.14,(-2.54,6.04,;-3.63,4.95,;-3.23,3.46,;-4.32,2.37,;-3.92,.89,;-5,-.21,;-4.29,-1.58,;-2.77,-1.32,;-2.54,.2,;-1.21,.97,;.13,.2,;.13,-1.34,;1.46,-2.11,;2.79,-1.34,;4.13,-2.11,;5.46,-1.34,;6.79,-2.11,;8.13,-1.34,;9.46,-2.11,;8.13,.2,;2.79,.2,;1.46,.97,;-4.69,-3.06,;-6.17,-3.46,;-6.57,-4.95,;-5.48,-6.04,;-4,-5.64,;-3.6,-4.15,;-6.49,.19,;-6.89,1.67,;-8.37,2.07,;-9.46,.98,;-9.06,-.5,;-7.58,-.9,)|
Structure:
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