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Target
VIM-1 metallo-beta-lactamase
Ligand
BDBM360985
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAYS
IC50
0.062±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent  US10221163 Publication Date 3/5/2019 
Target
Name:
VIM-1 metallo-beta-lactamase
Synonyms:
Beta-lactamase VIM-1 | VIM-1 | VIM-1 metallo-beta-lactamase | blaVIM-1
Type:
undefined
Mol. Mass.:
28014.53
Organism:
Klebsiella pneumoniae
Description:
Q5GN09
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM360985
Synonyms:
4'-((4R,5S)-4-methyl-2- oxooxazolidin-5-yl)-N4-((R)- pyrrolidin-3-yl)-2-(1H-tetrazol- 5-yl)-[1,1'-biphenyl]-3,4- disulfonamide | US10221163, Example 141 | US10544130, Example 141
Type:
Small organic molecule
Emp. Form.:
C21H24N8O6S2
Mol. Mass.:
548.595
SMILES:
C[C@H]1NC(=O)O[C@H]1c1ccc(cc1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r|
Structure:
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