Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3
Ligand
BDBM20254
Substrate
c-fos sis inducible element (hSIE)
Meas. Tech.
Electrophoretic Mobility Shift Assay (EMSA)
pH
7.8±n/a
Temperature
295.15±n/a K
IC50
1000±n/a nM
Citation
 Ren, Z; Cabell, LA; Schaefer, TS; McMurray, JS Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg Med Chem Lett 13:633-6 (2003) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3
Type:
Cytosolic Transcription Factor
Mol. Mass.:
88050.28
Organism:
Mus musculus (mouse)
Description:
Bacterially expressed protein was used in the FP assay.
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
  
Inhibitor
Name:
BDBM20254
Synonyms:
4-[(2S)-2-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[(1S)-1-{[(1S)-1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}ethyl]carbamoyl}propyl]carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid | LIFR (1028) derived peptide, 10 | Y(p)RPQAM
Type:
Phosphopeptide
Emp. Form.:
C35H56N11O12PS
Mol. Mass.:
885.924
SMILES:
[#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8]P([#8])([#8])=O)cc1)-[#7]-[#6](-[#6])=O)-[#6](-[#7])=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
c-fos sis inducible element (hSIE)
Synonyms:
32P-labeled c-fos sis inducible element (hSIE)
Type:
Oligonucleotide
Mol. Mass.:
2192.56
Organism:
n/a
Description:
hSIE derived from the c-fos gene promoter.
Residue:
24
Sequence:
AGCTTCATTTCCCGTAAATCCCTA