Reaction Details
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Hemagglutinin
Ligand
BDBM31169
Substrate
n/a
Meas. Tech.
Endonuclease Assay
pH
7.5±n/a
IC50
>100000±n/a nM
Comments
extracted
Citation
Lavoie, EJ; Bauman, JD; Sagong, HY; Arnold, E; Parhi, A; Das, K; Vijayan, SK; Patel, D Therapeutic hydroxyquinolones US Patent US9701638 Publication Date 7/11/2017 More Info.:
Target
Name:
Hemagglutinin
Synonyms:
HA | Hemagglutinin HA1 chain
Type:
Enzyme Catalytic Domain
Mol. Mass.:
63281.44
Organism:
Influenza A virus (strain swl A/California/04/2009 H1N1)
Description:
C3W5S1
Residue:
566
Sequence:
MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADTYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNIPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAISFWMCSNGSLQCRICI
Inhibitor
Name:
BDBM31169
Synonyms:
3-hydroxyquinolin-2(1H)-one, 23 | US9701638, 14
Type:
Small organic molecule
Emp. Form.:
C10H9NO2
Mol. Mass.:
175.184
SMILES:
Cc1c(O)c(=O)[nH]c2ccccc12
Structure:
