Reaction Details
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Free fatty acid receptor 1
Ligand
BDBM22485
Substrate
BDBM10852
Meas. Tech.
GPR40 FDSS Assay
Temperature
310.15±n/a K
EC50
2710±n/a nM
Comments
81% of the maximal response relative to the activity produced by linoleic acid.
Citation
Song, F; Lu, S; Gunnet, J; Xu, JZ; Wines, P; Proost, J; Liang, Y; Baumann, C; Lenhard, J; Murray, WV; Demarest, KT; Kuo, GH Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. J Med Chem 50:2807-17 (2007) [PubMed] Article More Info.:
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Inhibitor
Name:
BDBM22485
Synonyms:
3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 19 | 3-{4-[(3-methylbut-3-en-1-yl)oxy]phenyl}-3-phenylpropanoic acid
Type:
Small organic molecule
Emp. Form.:
C20H22O3
Mol. Mass.:
310.3869
SMILES:
CC(=C)CCOc1ccc(cc1)C(CC(O)=O)c1ccccc1
Structure:
Substrate