Reaction Details Report a problem with these data
Target
Phospholipase A2, major isoenzyme
Ligand
BDBM23762
Substrate
BDBM23751
Meas. Tech.
Fluorimetric Assay
IC50
>100000±n/a nM
Citation
 Boukli, L; Touaibia, M; Meddad-Belhabich, N; Djimdé, A; Park, CH; Kim, JJ; Yoon, JH; Lamouri, A; Heymans, F Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines. Bioorg Med Chem 16:1242-53 (2008) [PubMed]  Article 
Target
Name:
Phospholipase A2, major isoenzyme
Synonyms:
Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2
Type:
Hydrolase; monomer or homodimer
Mol. Mass.:
16279.83
Organism:
Sus scrofa (pig)
Description:
Purchased from Sigma.
Residue:
146
Sequence:
MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC
  
Inhibitor
Name:
BDBM23762
Synonyms:
3-({4-[(4-octadecylpiperazin-1-yl)carbonyl]phenyl}methyl)-4,5-dihydro-1,2,4-oxadiazol-5-one | PMS 1062 piperazine deriv., 26c
Type:
Small organic molecule
Emp. Form.:
C32H52N4O3
Mol. Mass.:
540.7803
SMILES:
CCCCCCCCCCCCCCCCCCN1CCN(CC1)C(=O)c1ccc(Cc2nc(=O)o[nH]2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23751
Synonyms:
1-hexadecanoyl-2-(10-pyrenyldecanoyl)-sn-glycero-3-phosphoglycerol | 1-palmitoyl-2-(10-pyrenyldecanoyl)-sn-glycero-3-phosphorylcholine | beta-pyC-10-PG
Type:
fluorescent phospholipid probe
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: