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Target
Bacterial leucyl aminopeptidase
Ligand
BDBM23986
Substrate
BDBM23972
Meas. Tech.
Enzyme Inhibition Assay
Ki
4000±n/a nM
Citation
 Albrecht, S; Defoin, A; Salomon, E; Tarnus, C; Wetterholm, A; Haeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem 14:7241-57 (2006) [PubMed]  Article 
Target
Name:
Bacterial leucyl aminopeptidase
Synonyms:
AMPX_VIBPR | Bacterial leucyl aminopeptidase precursor
Type:
PROTEIN
Mol. Mass.:
54213.72
Organism:
Vibrio proteolyticus
Description:
ChEMBL_1507540
Residue:
504
Sequence:
MKYTKTLLAMVLSATFCQAYAEDKVWISIGADANQTVMKSGAESILPNSVASSGQVWVGQVDVAQLAELSHNMHEEHNRCGGYMVHPSAQSAMAASAMPTTLASFVMPPITQQATVTAWLPQVDASQITGTISSLESFTNRFYTTTSGAQASDWIASEWQALSASLPNASVKQVSHSGYNQKSVVMTITGSEAPDEWIVIGGHLDSTIGSHTNEQSVAPGADDDASGIAAVTEVIRVLSENNFQPKRSIAFMAYAAEEVGLRGSQDLANQYKSEGKNVVSALQLDMTNYKGSAQDVVFITDYTDSNFTQYLTQLMDEYLPSLTYGFDTCGYACSDHASWHNAGYPAAMPFESKFNDYNPRIHTTQDTLANSDPTGSHAKKFTQLGLAYAIEMGSATGDTPTPGNQLEDGVPVTDLSGSRGSNVWYTFELETQKNLQITTSGGYGDLDLYVKFGSKASKQNWDCRPYLSGNNEVCTFNNASPGTYSVMLTGYSNYSGASLKASTF
  
Inhibitor
Name:
BDBM23986
Synonyms:
3,4-dihydro-1H-2-benzothiopyran-3-one | isothiochromanone, 4b
Type:
Small organic molecule
Emp. Form.:
C9H8OS
Mol. Mass.:
164.224
SMILES:
O=C1Cc2ccccc2CS1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23972
Synonyms:
(2S)-2-amino-4-methyl-N-(4-nitrophenyl)pentanamide | L-Leucine-p-nitroanilide | L-Leucine-para-nitroanilide
Type:
n/a
Emp. Form.:
C12H17N3O3
Mol. Mass.:
251.2817
SMILES:
CC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: