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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM377895
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
86010±n/a nM
Citation
 Foley, MA; Kuntz, KW; Mills, JE; Mitchell, LH; Munchhof, MJ; Harvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent  US10266526 Publication Date 4/23/2019 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM377895
Synonyms:
N-((1r,4r)-4-aminocyclohexyl)-3-(hydroxymethyl)benzamide | US10266526, Compound 26
Type:
Small organic molecule
Emp. Form.:
C14H20N2O2
Mol. Mass.:
248.3208
SMILES:
N[C@H]1CC[C@@H](CC1)NC(=O)c1cccc(CO)c1 |r,wU:1.0,wD:4.7,(6.67,2.69,;5.33,1.93,;5.33,.38,;4,-.38,;2.67,.38,;2.67,1.93,;4,2.69,;1.33,-.38,;,.38,;,1.93,;-1.33,-.38,;-1.33,-1.93,;-2.67,-2.69,;-4,-1.93,;-4,-.38,;-5.33,.38,;-6.67,-.38,;-2.67,.38,)|
Structure:
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