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Target
Proto-oncogene tyrosine-protein kinase Src [T341M]
Ligand
BDBM378887
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assays
IC50
3733±n/a nM
Citation
 Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent  US10266537 Publication Date 4/23/2019 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [T341M]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src (T341M) | SRC | SRC1 | SRC_HUMAN | c-src(T341M)
Type:
n/a
Mol. Mass.:
59868.69
Organism:
Homo sapiens (Human)
Description:
P12931[T341M]
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVMEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM378887
Synonyms:
US10266537, Compound 31
Type:
Small organic molecule
Emp. Form.:
C28H26F3N7O
Mol. Mass.:
533.5475
SMILES:
CN1CCC(CC1)n1nc(C#Cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)c2c(N)ncnc12
Structure:
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