Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM24356
Substrate
Carboxyfluorescein (FAM)-labeled acetylated peptide
Meas. Tech.
HDAC Inhibition Assay
IC50
737±n/a nM
Citation
 Chen, Y; Lopez-Sanchez, M; Savoy, DN; Billadeau, DD; Dow, GS; Kozikowski, AP A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. J Med Chem 51:3437-48 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM24356
Synonyms:
N-(4-{1-[2-(3-bromophenyl)-2-hydroxyethyl]-1H-1,2,3-triazol-5-yl}phenyl)-N'-hydroxyoctanediamide | Triazole Ligand, 12d
Type:
Small organic molecule
Emp. Form.:
C24H28BrN5O4
Mol. Mass.:
530.414
SMILES:
ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)-c1cnnn1CC(O)c1cccc(Br)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Carboxyfluorescein (FAM)-labeled acetylated peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA