Target

Ligand

Substrate

Meas. Tech.

Akt Inhibition Assay

pH

7.5±n/a

Temperature

295.15±n/a K

Citation

 Wu, Z; Hartnett, JC; Neilson, LA; Robinson, RG; Fu, S; Barnett, SF; Defeo-Jones, D; Jones, RE; Kral, AM; Huber, HE; Hartman, GD; Bilodeau, MT Development of pyridopyrimidines as potent Akt1/2 inhibitors. Bioorg Med Chem Lett 18:1274-9 (2008) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

RAC-alpha serine/threonine-protein kinase

Synonyms:

AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)

Type:

Enzyme

Mol. Mass.:

55681.25

Organism:

Homo sapiens (Human)

Description:

P31749

Residue:

480

Sequence:

MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM24867

Synonyms:

1-(2-aminophenyl)-3-[({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)amino]propan-1-one | CHEMBL252456 | Pyridopyrimidine, 12l

Type:

Small organic molecule

Emp. Form.:

C30H27N5OS

Mol. Mass.:

505.633

SMILES:

CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCC(=O)c2ccccc2N)cc1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

biotinylated Akt peptide substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

1734.89

Organism:

n/a

Description:

n/a

Residue:

17

Sequence:

ITINGGRARTSSFAEPG