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Target
Transthyretin
Ligand
BDBM138359
Substrate
n/a
Meas. Tech.
The FP assay
IC50
329±n/a nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US10278929 Publication Date 5/7/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM138359
Synonyms:
US10278929, Compound 9 | US11337935, Compound 9 | US8877795, 9
Type:
Small organic molecule
Emp. Form.:
C15H13N3O2
Mol. Mass.:
267.2826
SMILES:
CCOc1ccccc1-c1nc(no1)-c1ccncc1
Structure:
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