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Target
Geranylgeranyl pyrophosphate synthase
Ligand
BDBM25284
Substrate
BDBM25257
Meas. Tech.
GGPP Synthase Inhibition Assay
pH
7±n/a
Temperature
310.15±n/a K
IC50
2690±n/a nM
Citation
 K-M Chen, C; Hudock, MP; Zhang, Y; Guo, RT; Cao, R; No, JH; Liang, PH; Ko, TP; Chang, TH; Chang, SC; Song, Y; Axelson, J; Kumar, A; Wang, AH; Oldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem 51:5594-607 (2008) [PubMed]  Article 
Target
Name:
Geranylgeranyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:
Homooctamer; transferase
Mol. Mass.:
34867.94
Organism:
Homo sapiens (Human)
Description:
Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:
300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
  
Inhibitor
Name:
BDBM25284
Synonyms:
(1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phenyl]phenyl}-1-phosphonoethyl)phosphonic acid | BPH-675 | bisphosphonate, 6
Type:
Small organic molecule
Emp. Form.:
C24H23NO9P2S
Mol. Mass.:
563.453
SMILES:
OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O
Structure:
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Substrate
Name:
BDBM25257
Synonyms:
({hydroxy[(3-methylbut-3-en-1-yl)oxy]phosphoryl}oxy)phosphonic acid | [14C]IPP | [14C]isopentenyl diphosphate
Type:
radiolabeled substrate
Emp. Form.:
C5H12O7P2
Mol. Mass.:
246.0921
SMILES:
CC(=C)CCOP(O)(=O)OP(O)(O)=O
Structure:
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