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Target
Proto-oncogene tyrosine-protein kinase LCK
Ligand
BDBM26185
Substrate
Biotinylated Peptide Substrate
Meas. Tech.
Time Resolved Fluorescence Resonance Energy Transfer Assay
IC50
33±n/a nM
Citation
 Bamborough, P; Angell, RM; Bhamra, I; Brown, D; Bull, J; Christopher, JA; Cooper, AW; Fazal, LH; Giordano, I; Hind, L; Patel, VK; Ranshaw, LE; Sims, MJ; Skone, PA; Smith, KJ; Vickerstaff, E; Washington, M N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett 17:4363-8 (2007) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase LCK
Synonyms:
LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK
Type:
PROTEIN
Mol. Mass.:
57927.84
Organism:
Mus musculus
Description:
ChEMBL_806408
Residue:
509
Sequence:
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM26185
Synonyms:
2,4-dianilino pyrimidine, 42 | 3-{[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino}benzene-1-sulfonamide | GTC000120A
Type:
Small organic molecule
Emp. Form.:
C17H15N7O2S
Mol. Mass.:
381.412
SMILES:
NS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1622.70
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
ITINEEEEYFELV