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Target
Genome polyprotein
Ligand
BDBM263072
Substrate
n/a
Meas. Tech.
Norovirus Polymerase Inhibition Assay
EC50
>100000±n/a nM
Citation
 Bougher, III, JH; Changalvala, RV; Downey, AL; Drach, JC; Lanier, Jr., ER; McIver, AL; Robertson, BD; Selleseth, DW; Sethna, PB; Townsend, L; Ware, RW Pyrrolopyrimidine nucleosides and analogs thereof US Patent  US9708359 Publication Date 7/18/2017 
Target
Name:
Genome polyprotein
Synonyms:
Norovirus Polymerase
Type:
n/a
Mol. Mass.:
187250.43
Organism:
Murine norovirus 1
Description:
Q80J95
Residue:
1685
Sequence:
MRMATPSSAPSVRNTEKRKNKKASSKASVSFGAPSPLSSESEDEINYMTPPEQEAQPGALAALHAEGPLAGLPVTRSDARVLIFNEWEERKKSDPWLRLDMSDKAIFRRYPHLRPKEDRPDAPSHAEDAMDAKEPVIGSILEQDDHKFYHYSVYIGGGLVMGVNNPSAAVCQATIDVEKLHLWWRPVWEPRPLDSAELRKCVGMTVPYVATTVNCYQVCCWIVGIKDTWLKRAKISRDLPFYSPVQDWNVDPQEPFIPSKLRMVSDGILVALSAVIGRPIKNLLASVKPLNILNIVLSCDWTFSGIVNALILLAELFDIFWTPPDVTNWMISIFGEWQAEGPFDLALDVVPTLLGGIGMAFGLTSETIGRKLASTNSALKAAQEMGKFAIEVFKQIMAWIWPSEDPVPALLSNMEQAIIKNECQLENQLTAMLRDRNAGAEFLRSLDEEEQEVRKIAAKCGNSATTGTTNALLARISMARAAFEKARAEQTSRVRPVVIMVSGRPGIGKTCFCQNLAKRIAASLGDETSVGIIPRADVDHWDAYKGARVVLWDDFGMDNVVKDALRLQMLADTCPVTLNCDRIENKGKMFDSQVIIITTNQQTPVPLDYVNLEAVCRRIDFLVYAESPVVDDARARAPGDVNAVKAAMRPDYSHINFILAPQGGFDRQGNTPYGKGVTKIIGATALCARAVALVHERHDDFGLQNKVYDFDAGKVTAFKAMAADAGIPWYKMAAIGCKAMGCTCVEEAMHLLKDYEVAPCQVIYNGATYNVSCIKGAPMVEKVKEPELPKTLVNCVRRIKEARLRCYCRMAADVITSILQAAGTAFSIYHQIEKRSRPSFYWDGYTYRDGPGSFDIFEDDDDGWYHSEGKKGKNKKGRGRPGVFRTRGLTDEEYDEFKKRRESRGGKYSIDDYLADREREEELLERDEEEAIFGDGFGLKATRRSRKAERAKLGLVSGGDIRARKPIDWNVVGPSWADDDRQVDYGEKINFEAPVSIWSRVVQFGTGWGFWVSGHVFITAKHVAPPKGTEIFGRKPGDFTVTSSGDFLKYYFTSAVRPDIPAMVLENGCQEGVVASVLVKRASGEMLALAVRMGSQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDCGCPYVYKKGNTWVVIGVHVAATRSGNTVIAATHGEPTLEALEFQGPPMLPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCPCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEKYYRTVASRVSKEAAQSGIEMVVPRHRSVLRWVRFGTMDAETPQERSAVFVNEDE
  
Inhibitor
Name:
BDBM263072
Synonyms:
US9708359, 1 | US9708359, 122 | US9708359, 38 | US9708359, 6
Type:
Small organic molecule
Emp. Form.:
C13H17N5O5
Mol. Mass.:
323.3046
SMILES:
Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O |r|
Structure:
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