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Target
Proto-oncogene tyrosine-protein kinase receptor Ret [638-1114]
Ligand
BDBM296869
Substrate
n/a
Meas. Tech.
RET Kinase Enzymatic Assay
IC50
<10±n/a nM
Citation
 Demartino, MP; Guan, HA Compounds as rearranged during transfection (RET) inhibitors US Patent  US10292975 Publication Date 5/21/2019 
Target
Name:
Proto-oncogene tyrosine-protein kinase receptor Ret [638-1114]
Synonyms:
CDHF12 | CDHR16 | PTC | Proto-oncogene tyrosine-protein kinase receptor Ret | RET | RET51 | RET_HUMAN
Type:
Protein
Mol. Mass.:
53601.71
Organism:
Homo sapiens (Human)
Description:
P07949[638-1114]
Residue:
477
Sequence:
IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
  
Inhibitor
Name:
BDBM296869
Synonyms:
US10111866, Example 2 | US10292975, Example 2 | US10709695, Example 2
Type:
Small organic molecule
Emp. Form.:
C26H27F4N3O4
Mol. Mass.:
521.5039
SMILES:
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(OCCN(C)C)cc(c2)C(F)(F)F)c(F)c1
Structure:
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