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Target
Interleukin-2
Ligand
BDBM387273
Substrate
n/a
Meas. Tech.
Inhibition of IL-2 secretion
IC50
<100.0±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Interleukin-2
Synonyms:
IL-2 | IL2 | IL2_HUMAN | INN=Aldesleukin | Interleukin-2 | Interleukin-2 (IL-2) | T-cell growth factor | TCGF
Type:
Enzyme
Mol. Mass.:
17630.05
Organism:
Homo sapiens (Human)
Description:
P60568
Residue:
153
Sequence:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
  
Inhibitor
Name:
BDBM387273
Synonyms:
US10292981, Example 135
Type:
Small organic molecule
Emp. Form.:
C25H21F2N3O3
Mol. Mass.:
449.4493
SMILES:
CNc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O |t:28|
Structure:
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