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Target
Nuclear factor of activated T-cells, cytoplasmic 2
Ligand
BDBM387264
Substrate
n/a
Meas. Tech.
NFAT Transcriptional Activity
IC50
<500±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Nuclear factor of activated T-cells, cytoplasmic 2
Synonyms:
NF-ATc2 | NF-ATp | NFAC2_HUMAN | NFAT pre-existing subunit | NFAT1 | NFATC2 | NFATP | T-cell transcription factor NFAT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100156.24
Organism:
Homo sapiens (Human)
Description:
Q13469
Residue:
925
Sequence:
MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPPARNQT
  
Inhibitor
Name:
BDBM387264
Synonyms:
N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2′-methyl-[1,1′- biphenyl]-4-yl)-2,6- difluorobenzamide | US10292981, Example 29
Type:
Small organic molecule
Emp. Form.:
C25H20F2N2O3
Mol. Mass.:
434.4347
SMILES:
Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O |t:27|
Structure:
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