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Target
Nuclear factor of activated T-cells, cytoplasmic 2
Ligand
BDBM387315
Substrate
n/a
Meas. Tech.
NFAT Transcriptional Activity
IC50
<500±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Nuclear factor of activated T-cells, cytoplasmic 2
Synonyms:
NF-ATc2 | NF-ATp | NFAC2_HUMAN | NFAT pre-existing subunit | NFAT1 | NFATC2 | NFATP | T-cell transcription factor NFAT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100156.24
Organism:
Homo sapiens (Human)
Description:
Q13469
Residue:
925
Sequence:
MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPPARNQT
  
Inhibitor
Name:
BDBM387315
Synonyms:
4- Methyl-N-(2′-methyl- 3′-(4-methyl-5-oxo- 4,5-dihydro-1,3,4- oxadiazol-2-yl)-[1,1′- biphenyl]-4-yl)-1,2,3- thiadiazole-5- carboxamide | US10292981, Example 50
Type:
Small organic molecule
Emp. Form.:
C20H17N5O3S
Mol. Mass.:
407.446
SMILES:
Cc1nnsc1C(=O)Nc1ccc(cc1)-c1cccc(-c2nn(C)c(=O)o2)c1C
Structure:
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