Reaction Details Report a problem with these data
Target
Nuclear factor of activated T-cells, cytoplasmic 2
Ligand
BDBM387280
Substrate
n/a
Meas. Tech.
NFAT Transcriptional Activity
IC50
<500±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Nuclear factor of activated T-cells, cytoplasmic 2
Synonyms:
NF-ATc2 | NF-ATp | NFAC2_HUMAN | NFAT pre-existing subunit | NFAT1 | NFATC2 | NFATP | T-cell transcription factor NFAT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100156.24
Organism:
Homo sapiens (Human)
Description:
Q13469
Residue:
925
Sequence:
MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPPARNQT
  
Inhibitor
Name:
BDBM387280
Synonyms:
N-(2,6- Difluorophenyl)-5-(2- methyl-3-(4-methyl- 5-oxo-4,5-dihydro- 1,3,4-oxadiazol-2- yl)phenyl)thiophene- 2-carboxamide | US10292981, Example 176
Type:
Small organic molecule
Emp. Form.:
C21H15F2N3O3S
Mol. Mass.:
427.424
SMILES:
Cc1c(cccc1-c1nn(C)c(=O)o1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F
Structure:
Search PDB for entries with ligand similarity: