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Target
Oxysterols receptor LXR-beta
Ligand
BDBM27274
Substrate
biotinylated SRC-1 peptide
Meas. Tech.
HTRF Cofactor Peptide Recruitment Assay
pH
7.5±n/a
Temperature
295.15±n/a K
EC50
1780±n/a nM
Citation
 Kher, S; Lake, K; Sircar, I; Pannala, M; Bakir, F; Zapf, J; Xu, K; Zhang, SH; Liu, J; Morera, L; Sakurai, N; Jack, R; Cheng, JF 2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists. Bioorg Med Chem Lett 17:4442-6 (2007) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM27274
Synonyms:
N-{2-[4-(1-benzoyl-1H-indol-2-yl)phenyl]ethyl}benzamide | benzamide derivative, 9
Type:
Small organic molecule
Emp. Form.:
C30H24N2O2
Mol. Mass.:
444.5238
SMILES:
O=C(NCCc1ccc(cc1)-c1cc2ccccc2n1C(=O)c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
biotinylated SRC-1 peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3157.52
Organism:
n/a
Description:
A biotinylated peptide comprises amino acids 675-699 of steroid receptor coactivator 1 (SRC1).
Residue:
28
Sequence:
CPSSHSSLTERHKILHRLLQEGSPSCNH