Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM15581
Substrate
BDBM29135
Meas. Tech.
MAO Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
4.5±0.32 nM
Citation
Chimenti, F; Fioravanti, R; Bolasco, A; Chimenti, P; Secci, D; Rossi, F; Yáñez, M; Orallo, F; Ortuso, F; Alcaro, S Chalcones: a valid scaffold for monoamine oxidases inhibitors. J Med Chem 52:2818-24 (2009) [PubMed] Article
More Info.:
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Inhibitor
Name:
BDBM15581
Synonyms:
CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine | US8633208, Clorgyline | US9603833, Clorgyline | [3-(2,4-dichlorophenoxy)propyl](methyl)prop-2-yn-1-ylamine
Type:
Small organic molecule
Emp. Form.:
C13H15Cl2NO
Mol. Mass.:
272.17
SMILES:
CN(CCCOc1ccc(Cl)cc1Cl)CC#C