Reaction Details Report a problem with these data
Target
Protein polybromo-1 [645-766]
Ligand
BDBM394507
Substrate
n/a
Meas. Tech.
Polybromodomain-1 BromoDomain-5 (PB1-BD5) SM TR-FRET Binding Assay
IC50
15.9±n/a nM
Citation
 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Therapeutic compounds and uses thereof US Patent  US10308614 Publication Date 6/4/2019 
Target
Name:
Protein polybromo-1 [645-766]
Synonyms:
BAF180 | BRG1-associated factor 180 | Histidine-Flag-PB1-BD5 Bromodomain (aa 645-766) | PB1 | PB1_HUMAN | PBRM1 | Protein polybromo-1 (aa 645-766) | Q86U86(S645-D766)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14410.58
Organism:
Homo sapiens (Human)
Description:
Q86U86(S645-D766)
Residue:
122
Sequence:
SGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGD
  
Inhibitor
Name:
BDBM394507
Synonyms:
2-(6-amino-5-(3-methyl-4-(methylsulfonyl)piperazin-1-yl)pyridazin-3-yl)phenol | US10308614, Example 108
Type:
Small organic molecule
Emp. Form.:
C16H21N5O3S
Mol. Mass.:
363.435
SMILES:
CC1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O
Structure:
Search PDB for entries with ligand similarity: