Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Assay

Citation

 Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. Bioorg Med Chem Lett 19:3664-8 (2009) [PubMed]  Article Copy BDB DOI

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Name:

Cathepsin D

Synonyms:

CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor

Type:

Enzyme

Mol. Mass.:

44551.72

Organism:

Homo sapiens (Human)

Description:

Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.

Residue:

412

Sequence:

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

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Name:

BDBM26502

Synonyms:

3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide | BMCL181022 Compound 7 | BMCL193664 Compound 24 | BMCL193664 Compound 9 | BMCL193669 Compound 8 | sultam hydroxyethylamine (HEA) derivative, 1

Type:

Small organic molecule

Emp. Form.:

C31H37F3N4O4S

Mol. Mass.:

618.71

SMILES:

CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O |r|

Structure:

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Similarity to this molecule at least:

Name:

Fluorescent Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

2030.30

Organism:

n/a

Description:

n/a

Residue:

18

Sequence:

FAMSEVNLDAEFKTAMRA