Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM395364
Substrate
n/a
Meas. Tech.
Measurement of DGAT1 Inhibitory Activity
IC50
1.20±n/a nM
Citation
 Saruta, K; Hayashi, N; Sakurai, O; Sawamoto, H; Ooboki, E Aromatic heterocyclic compound US Patent  US10308636 Publication Date 6/4/2019 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM395364
Synonyms:
US10308636, Example 46-5
Type:
Small organic molecule
Emp. Form.:
C22H21F4N3O
Mol. Mass.:
419.4153
SMILES:
Fc1ccccc1OC[C@H]1CC[C@@H](CC1)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F |r,wU:12.16,wD:9.9,(-7.12,-1.57,;-7.12,-3.11,;-8.5,-3.85,;-8.45,-5.42,;-7.12,-6.19,;-5.79,-5.42,;-5.79,-3.88,;-4.45,-3.11,;-3.12,-3.88,;-1.78,-3.11,;-.45,-3.88,;.88,-3.11,;.88,-1.57,;-.45,-.8,;-1.78,-1.57,;2.22,-.8,;2.22,.74,;3.55,1.51,;4.88,.74,;4.88,-.8,;3.55,-1.57,;6.22,1.51,;6.22,3.05,;7.7,3.56,;8.59,2.28,;7.68,1.03,;8.17,5.03,;8.65,6.49,;9.64,4.55,;6.71,5.5,)|
Structure:
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