Reaction Details Report a problem with these data
Target
Pepsin A
Ligand
BDBM32387
Substrate
Pepsin Substrate Peptide
Meas. Tech.
Enzyme Inhibition Assay
Temperature
298.15±n/a K
Ki
3900±n/a nM
Comments
extracted
Citation
 Blum, A; Böttcher, J; Sammet, B; Luksch, T; Heine, A; Klebe, G; Diederich, WE Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors. Bioorg Med Chem 16:8574-86 (2008) [PubMed]  Article 
Target
Name:
Pepsin A
Synonyms:
PEPA_PIG | PGA | Pepsin | Pepsin A precursor
Type:
Enzyme
Mol. Mass.:
41232.87
Organism:
Porcine
Description:
n/a
Residue:
385
Sequence:
MKWLLLLSLVVLSECLVKVPLVRKKSLRQNLIKNGKLKDFLKTHKHNPASKYFPEAAALIGDEPLENYLDTEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSVYCSSLACSDHNQFNPDDSSTFEATSQELSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISASGATPVFDNLWDQGLVSQDLFSVYLSSNDDSGSVVLLGGIDSSYYTGSLNWVPVSVEGYWQITLDSITMDGETIACSGGCQAIVDTGTSLLTGPTSAIANIQSDIGASENSDGEMVISCSSIDSLPDIVFTINGVQYPLSPSAYILQDDDSCTSGFEGMDVPTSSGELWILGDVFIRQYYTVFDRANNKVGLAPVA
  
Inhibitor
Name:
BDBM32387
Synonyms:
phenyl-substituted sulfonamides, 6d
Type:
Small organic molecule
Emp. Form.:
C30H35N5O4S2
Mol. Mass.:
593.76
SMILES:
Nc1ccc(cc1)S(=O)(=O)N(CCNCCN(Cc1ccccc1)S(=O)(=O)c1ccc(N)cc1)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Pepsin Substrate Peptide
Synonyms:
n/a
Type:
fluorogenic substrate
Mol. Mass.:
2590.28
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
ATHRILENLEPNPHEGLNARGNH