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Target
Bcl-2-related protein A1
Ligand
BDBM33127
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
2310±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33127
Synonyms:
MLS000392290 | N-[3-(3-chloro-4-methyl-anilino)-1,4-diketo-2-naphthyl]benzamide | N-[3-(3-chloro-4-methylanilino)-1,4-dioxo-2-naphthalenyl]benzamide | N-[3-(3-chloro-4-methylanilino)-1,4-dioxonaphthalen-2-yl]benzamide | N-[3-[(3-chloranyl-4-methyl-phenyl)amino]-1,4-bis(oxidanylidene)naphthalen-2-yl]benzamide | SMR000261286 | cid_5082182
Type:
Small organic molecule
Emp. Form.:
C24H17ClN2O3
Mol. Mass.:
416.856
SMILES:
Cc1ccc(NC2=C(NC(=O)c3ccccc3)C(=O)c3ccccc3C2=O)cc1Cl |c:6|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR