Target
Bcl-2-related protein A1
Ligand
BDBM33149
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
17760±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33149
Synonyms:
2-acetamido-4,6-dibromo-7-hydroxy-1-benzothiophene-3-carboxylic acid ethyl ester | 2-acetamido-4,6-dibromo-7-hydroxy-benzothiophene-3-carboxylic acid ethyl ester | MLS000698997 | SMR000230889 | cid_1069019 | ethyl 2-(acetylamino)-4,6-dibromo-7-hydroxy-1-benzothiophene-3-carboxylate | ethyl 2-acetamido-4,6-bis(bromanyl)-7-oxidanyl-1-benzothiophene-3-carboxylate | ethyl 2-acetamido-4,6-dibromo-7-hydroxy-1-benzothiophene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C13H11Br2NO4S
Mol. Mass.:
437.104
SMILES:
CCOC(=O)c1c(NC(C)=O)sc2c(O)c(Br)cc(Br)c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR