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Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM403158
Substrate
n/a
Meas. Tech.
MTT assay
EC50
100.0±n/a nM
Citation
 Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent  US10329303 Publication Date 6/25/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM403158
Synonyms:
US10329303, Example 17
Type:
Small organic molecule
Emp. Form.:
C27H31FN4O3S
Mol. Mass.:
510.623
SMILES:
CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(-c3cc(C)cc(CO)c3F)c2c(=O)n(C2CC2)c1=O |(-3.39,-5.89,;-3.39,-4.35,;-4.73,-3.58,;-2.06,-3.58,;-2.06,-2.04,;-.72,-1.27,;.74,-1.75,;1.65,-.5,;3.19,-.5,;3.96,-1.84,;3.48,-3.3,;2.15,-4.07,;4.73,-4.21,;5.97,-3.3,;5.5,-1.84,;6.27,-.5,;.74,.74,;1.14,2.23,;.05,3.32,;.45,4.81,;-.64,5.89,;1.94,5.2,;3.02,4.12,;4.51,4.51,;5.6,3.42,;2.63,2.63,;3.72,1.54,;-.72,.27,;-2.06,1.04,;-2.06,2.58,;-3.39,.27,;-4.73,1.04,;-6.27,1.04,;-5.5,2.37,;-3.39,-1.27,;-4.73,-2.04,)|
Structure:
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