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Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM403228
Substrate
n/a
Meas. Tech.
MTT assay
EC50
80.0±n/a nM
Citation
 Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent  US10329303 Publication Date 6/25/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM403228
Synonyms:
US10329303, Example 27
Type:
Small organic molecule
Emp. Form.:
C29H27F2N3O2
Mol. Mass.:
487.5404
SMILES:
CC(C)Cc1nn(C)c(=O)c2c(-c3ccc(F)c(CO)c3F)n(Cc3cccc4ccccc34)cc12 |(-5.32,-6.29,;-5.32,-4.75,;-6.65,-3.98,;-3.98,-3.98,;-3.98,-2.44,;-5.32,-1.67,;-5.32,-.13,;-6.65,.64,;-3.98,.64,;-3.98,2.18,;-2.65,-.13,;-1.18,.34,;-.79,1.83,;-1.88,2.92,;-1.48,4.41,;.01,4.81,;.41,6.29,;1.1,3.72,;2.59,4.12,;2.99,5.6,;.7,2.23,;1.79,1.14,;-.28,-.9,;1.26,-.9,;2.03,-2.24,;1.26,-3.57,;2.03,-4.9,;3.57,-4.9,;4.34,-3.57,;5.88,-3.57,;6.65,-2.24,;5.88,-.9,;4.34,-.9,;3.57,-2.24,;-1.18,-2.15,;-2.65,-1.67,)|
Structure:
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