Reaction Details Report a problem with these data
Target
Protein Wnt-2
Ligand
BDBM36413
Substrate
n/a
Meas. Tech.
Wnt Inhibition Assay
pH
7.4±0
Temperature
277.15±0 K
IC50
40±0.0 nM
Citation
 Chen, B; Dodge, ME; Tang, W; Lu, J; Ma, Z; Fan, CW; Wei, S; Hao, W; Kilgore, J; Williams, NS; Roth, MG; Amatruda, JF; Chen, C; Lum, L Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5:100-7 (2009) [PubMed]  Article 
Target
Name:
Protein Wnt-2
Synonyms:
Irp | Protein Wnt | WNT2_MOUSE | Wnt-2 | Wnt2
Type:
Protein
Mol. Mass.:
40507.27
Organism:
Mus musculus (Mouse)
Description:
P21552
Residue:
360
Sequence:
MNVPLGGIWLWLPLLLTWLTPEVSSSWWYMRATGGSSRVMCDNVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGSAKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCKAPKSADWATPT
  
Inhibitor
Name:
BDBM36413
Synonyms:
CID15995771 | trans-N-Benzyl-4-((1-((6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)cyclohexanecarboxamide, 3
Type:
Small organic molecule
Emp. Form.:
C33H33N5O4
Mol. Mass.:
563.6462
SMILES:
[H][C@]1(Cn2c(=O)n(Cc3cc(=O)n4c(C)cccc4n3)c3ccccc3c2=O)CC[C@@]([H])(CC1)C(=O)NCc1ccccc1 |r,wU:1.1,30.34,wD:1.0,30.38,(-.8,-3.01,;.38,-4,;-1.16,-4,;-1.92,-2.67,;-3.46,-2.67,;-4.23,-4,;-4.23,-1.33,;-5.77,-1.33,;-6.54,-0,;-8.08,-0,;-8.85,1.33,;-10.38,1.33,;-8.08,2.66,;-8.85,4,;-10.38,4,;-8.08,5.33,;-6.54,5.33,;-5.77,4,;-6.54,2.66,;-5.77,1.33,;-3.46,0,;-4.23,1.33,;-3.46,2.67,;-1.92,2.67,;-1.15,1.33,;-1.92,0,;-1.15,-1.33,;.38,-1.33,;1.15,-2.66,;2.69,-2.66,;3.46,-4,;4.33,-5.27,;2.69,-5.33,;1.15,-5.33,;5,-4,;5.77,-2.67,;5.77,-5.33,;7.3,-5.33,;8.07,-4,;7.3,-2.66,;8.07,-1.33,;9.61,-1.33,;10.38,-2.66,;9.61,-4,)|
Structure:
Search PDB for entries with ligand similarity: