Reaction Details Report a problem with these data
Target
Protein Wnt-2
Ligand
BDBM36414
Substrate
n/a
Meas. Tech.
Wnt Inhibition Assay
pH
7.4±0
Temperature
277.15±0 K
IC50
25±0.0 nM
Citation
 Chen, B; Dodge, ME; Tang, W; Lu, J; Ma, Z; Fan, CW; Wei, S; Hao, W; Kilgore, J; Williams, NS; Roth, MG; Amatruda, JF; Chen, C; Lum, L Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5:100-7 (2009) [PubMed]  Article 
Target
Name:
Protein Wnt-2
Synonyms:
Irp | Protein Wnt | WNT2_MOUSE | Wnt-2 | Wnt2
Type:
Protein
Mol. Mass.:
40507.27
Organism:
Mus musculus (Mouse)
Description:
P21552
Residue:
360
Sequence:
MNVPLGGIWLWLPLLLTWLTPEVSSSWWYMRATGGSSRVMCDNVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGSAKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCKAPKSADWATPT
  
Inhibitor
Name:
BDBM36414
Synonyms:
CID15993586 | trans-N-Benzyl-4-((1-((2-cyanophenyl)methyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)cyclohexanecarboxamide, 4
Type:
Small organic molecule
Emp. Form.:
C31H30N4O3
Mol. Mass.:
506.5949
SMILES:
[H][C@]1(Cn2c(=O)n(Cc3ccccc3C#N)c3ccccc3c2=O)CC[C@@]([H])(CC1)C(=O)NCc1ccccc1 |r,wU:1.1,26.29,wD:1.0,26.33,(-1.18,-1.6,;0,-2.59,;-1.54,-2.59,;-2.31,-1.26,;-3.85,-1.26,;-4.61,-2.59,;-4.62,.07,;-6.15,.07,;-6.92,1.4,;-6.15,2.74,;-6.92,4.07,;-8.46,4.07,;-9.23,2.74,;-8.46,1.4,;-9.23,.07,;-10,-1.26,;-3.85,1.41,;-4.62,2.74,;-3.85,4.08,;-2.31,4.08,;-1.54,2.74,;-2.31,1.41,;-1.54,.07,;,.07,;.77,-1.25,;2.31,-1.25,;3.08,-2.59,;3.94,-3.87,;2.31,-3.92,;.77,-3.92,;4.62,-2.59,;5.38,-1.26,;5.38,-3.92,;6.92,-3.92,;7.69,-2.59,;6.92,-1.25,;7.69,.08,;9.23,.08,;10,-1.25,;9.23,-2.59,)|
Structure:
Search PDB for entries with ligand similarity: