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Target
G-protein coupled estrogen receptor 1
Ligand
BDBM36493
Substrate
n/a
Meas. Tech.
Competitive Binding Assay
Ki
16±0.0 nM
Citation
 Revankar, CM; Mitchell, HD; Field, AS; Burai, R; Corona, C; Ramesh, C; Sklar, LA; Arterburn, JB; Prossnitz, ER Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol 2:536-44 (2007) [PubMed]  Article 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM36493
Synonyms:
E2-NB
Type:
Small organic molecule
Emp. Form.:
C32H39NO4
Mol. Mass.:
501.6564
SMILES:
CC(C)(C)OC(=O)NCc1ccc(cc1)C#C[C@]1(O)CCC2C3CCc4cc(O)ccc4C3CC[C@]12C |r|
Structure:
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