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Target
Vitamin D-binding protein
Ligand
BDBM36718
Substrate
n/a
Meas. Tech.
DBP Binding Assay
pH
7.4±0
Temperature
277.15±0 K
IC50
>1000±0.0 nM
Citation
 Boehm, MF; Fitzgerald, P; Zou, A; Elgort, MG; Bischoff, ED; Mere, L; Mais, DE; Bissonnette, RP; Heyman, RA; Nadzan, AM; Reichman, M; Allegretto, EA Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3. Chem Biol 6:265-75 (1999) [PubMed]  Article 
Target
Name:
Vitamin D-binding protein
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
52955.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_622880
Residue:
474
Sequence:
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
  
Inhibitor
Name:
BDBM36718
Synonyms:
LG190090
Type:
Small organic molecule
Emp. Form.:
C27H34Cl2O4
Mol. Mass.:
493.462
SMILES:
CC(C)(C)C(=O)COc1ccc(cc1Cl)C(C)(C)c1ccc(OCC(=O)C(C)(C)C)c(Cl)c1
Structure:
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