Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha [200-419]/gamma [183-417]
Ligand
BDBM36810
Substrate
n/a
Meas. Tech.
Competitive Assay
pH
8±0
Temperature
277.15±0 K
Ki
1.0±0.0 nM
Citation
 Géhin, M; Vivat, V; Wurtz, JM; Losson, R; Chambon, P; Moras, D; Gronemeyer, H Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol 6:519-29 (1999) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha [200-419]/gamma [183-417]
Synonyms:
Retinoic Acid Receptors Gamma / Alpha
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Retinoic acid receptor gamma [183-417]
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic Acid Receptor, gamma
Type:
Ligand-binding domain
Mol. Mass.:
26502.27
Organism:
Homo sapiens (Human)
Description:
P13631[183-417]
Residue:
235
Sequence:
SPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLE
  
Component 2
Name:
Retinoic acid receptor alpha [200-419]
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic Acid Receptor, alpha
Type:
Ligand-binding domain
Mol. Mass.:
24746.59
Organism:
Homo sapiens (Human)
Description:
P10276[200-419]
Residue:
220
Sequence:
PALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
  
Inhibitor
Name:
BDBM36810
Synonyms:
BMS753 | US9963439, BMS753
Type:
Small organic molecule
Emp. Form.:
C21H21NO4
Mol. Mass.:
351.3957
SMILES:
CC1(C)C(=O)C(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: