Reaction Details Report a problem with these data
Target
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Ligand
BDBM36943
Substrate
n/a
Meas. Tech.
Dose-response cell-based assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA)
IC50
5170±n/a nM
Citation
 PubChem, PC Dose-response cell-based assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) PubChem Bioassay (2007)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Synonyms:
NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor ROR-alpha (Alpha-2) | Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). | RORA | RORA_HUMAN | RZRA
Type:
PROTEIN
Mol. Mass.:
63033.59
Organism:
Homo sapiens (Human)
Description:
EBI_101591
Residue:
556
Sequence:
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM36943
Synonyms:
(8-fluoro-5H-pyrimid[5,4-b]indol-4-yl)-(3-isopropoxypropyl)amine | 8-fluoranyl-N-(3-propan-2-yloxypropyl)-5H-pyrimido[5,4-b]indol-4-amine | 8-fluoro-N-(3-propan-2-yloxypropyl)-5H-pyrimido[5,4-b]indol-4-amine | MLS000040860 | SMR000045926 | cid_664895
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O
Mol. Mass.:
302.3467
SMILES:
CC(C)OCCCNc1ncnc2c3cc(F)ccc3[nH]c12
Structure:
Search PDB for entries with ligand similarity: