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Target
Alkaline phosphatase, germ cell type
Ligand
BDBM39628
Substrate
n/a
Meas. Tech.
Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase
IC50
4100±270 nM
Citation
 PubChem, PC Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase PubChem Bioassay (2007)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM39628
Synonyms:
(E)-2-(benzenesulfonyl)-3-(3,4-dihydroxyphenyl)-2-propenenitrile | (E)-2-(benzenesulfonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile | (E)-2-besyl-3-(3,4-dihydroxyphenyl)acrylonitrile | (E)-3-[3,4-bis(oxidanyl)phenyl]-2-(phenylsulfonyl)prop-2-enenitrile | 3-(3,4-dihydroxyphenyl)-2-(phenylsulfonyl)acrylonitrile | MLS000050507 | SMR000076437 | cid_978069
Type:
Small organic molecule
Emp. Form.:
C15H11NO4S
Mol. Mass.:
301.317
SMILES:
Oc1ccc(\C=C(/C#N)S(=O)(=O)c2ccccc2)cc1O
Structure:
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