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Target
Mitogen-activated protein kinase 10
Ligand
BDBM42594
Substrate
n/a
Meas. Tech.
Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3)
IC50
6628±n/a nM
Citation
 PubChem, PC Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3) PubChem Bioassay (2008)[AID] 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM42594
Synonyms:
4-Amino-2-[(2-ethoxycarbonyl-phenylcarbamoyl)-methylsulfanyl]-pyrimidine-5-carboxylic acid ethyl ester | 4-amino-2-[[2-(2-carbethoxyanilino)-2-keto-ethyl]thio]pyrimidine-5-carboxylic acid ethyl ester | 4-amino-2-[[2-(2-ethoxycarbonylanilino)-2-oxoethyl]thio]-5-pyrimidinecarboxylic acid ethyl ester | MLS000070312 | SMR000001887 | cid_649913 | ethyl 4-amino-2-[2-(2-ethoxycarbonylanilino)-2-oxoethyl]sulfanylpyrimidine-5-carboxylate | ethyl 4-azanyl-2-[2-[(2-ethoxycarbonylphenyl)amino]-2-oxidanylidene-ethyl]sulfanyl-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H20N4O5S
Mol. Mass.:
404.44
SMILES:
CCOC(=O)c1ccccc1NC(=O)CSc1ncc(C(=O)OCC)c(N)n1
Structure:
Search PDB for entries with ligand similarity: