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Target
Mitogen-activated protein kinase 10
Ligand
BDBM42618
Substrate
n/a
Meas. Tech.
Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3)
IC50
8417±n/a nM
Citation
 PubChem, PC Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3) PubChem Bioassay (2008)[AID] 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM42618
Synonyms:
(Z)-2-cyano-3-(veratrylamino)but-2-enamide | (Z)-2-cyano-3-[(3,4-dimethoxyphenyl)methylamino]-2-butenamide | (Z)-2-cyano-3-[(3,4-dimethoxyphenyl)methylamino]but-2-enamide | MLS000039238 | SMR000039871 | cid_658795
Type:
Small organic molecule
Emp. Form.:
C14H17N3O3
Mol. Mass.:
275.3031
SMILES:
COc1ccc(CN=C(C)C(C#N)C(N)=O)cc1OC |w:7.6|
Structure:
Search PDB for entries with ligand similarity: