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Target
Regulator of G-protein signaling 8
Ligand
BDBM47783
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47783
Synonyms:
4-[(2-chloranyl-6-fluoranyl-phenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione | 4-[(2-chloro-6-fluoro-benzylidene)amino]-3-(3-pyridyl)-1H-1,2,4-triazole-5-thione | 4-[(2-chloro-6-fluorobenzylidene)amino]-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol | 4-[(2-chloro-6-fluorophenyl)methylideneamino]-3-(3-pyridinyl)-1H-1,2,4-triazole-5-thione | 4-[(2-chloro-6-fluorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione | MLS000677590 | SMR000271762 | cid_806179
Type:
Small organic molecule
Emp. Form.:
C14H9ClFN5S
Mol. Mass.:
333.771
SMILES:
Fc1cccc(Cl)c1C=Nn1c(n[nH]c1=S)-c1cccnc1 |w:9.10|
Structure:
Search PDB for entries with ligand similarity: