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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50158
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
2318.988161±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50158
Synonyms:
(2E,3Z)-2-[ethoxy(hydroxy)methylene]-3-(4-propylbenzylidene)tetralin-1,4-quinone | (2E,3Z)-2-[ethoxy(hydroxy)methylidene]-3-[(4-propylphenyl)methylidene]naphthalene-1,4-dione | (2E,3Z)-2-[ethoxy(oxidanyl)methylidene]-3-[(4-propylphenyl)methylidene]naphthalene-1,4-dione | MLS000571357 | SMR000193442 | cid_5337202 | ethyl 1-hydroxy-4-oxo-3-(4-propylbenzylidene)-3,4-dihydro-2-naphthalenecarboxylate
Type:
Small organic molecule
Emp. Form.:
C23H22O4
Mol. Mass.:
362.4184
SMILES:
CCCc1ccc(CC2=C(C(=O)OCC)C(=O)c3ccccc3C2=O)cc1 |c:8|
Structure:
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