Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53454
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.2e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53454
Synonyms:
(2E)-2-[(2Z)-2-(3-methoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-2-[(2Z)-2-(3-methoxy-4-oxo-1-cyclohexa-2,5-dienylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-2-[(2Z)-2-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-2-[(2Z)-2-(4-keto-3-methoxy-cyclohexa-2,5-dien-1-ylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | 2-[2-(4-Hydroxy-3-methoxy-phenyl)-vinyl]-3-(4-methoxy-phenyl)-3H-quinazolin-4-one | MLS001203348 | O-acyl oxime isatin derivative, 3 | SMR000516541 | cid_5762771
Type:
Small organic molecule
Emp. Form.:
C24H20N2O4
Mol. Mass.:
400.4266
SMILES:
COc1ccc(cc1)-n1c(C=Cc2ccc(O)c(OC)c2)nc2ccccc2c1=O |w:10.10|
Structure:
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