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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53473
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
5.8e+3±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53473
Synonyms:
(4,5-dimethylthiazol-2-yl)-(piperonylideneamino)amine | MLS001202738 | N-(1,3-benzodioxol-5-ylmethylideneamino)-4,5-dimethyl-1,3-thiazol-2-amine | N-(1,3-benzodioxol-5-ylmethylideneamino)-4,5-dimethyl-2-thiazolamine | N-Benzo[1,3]dioxol-5-ylmethylene-N'-(4,5-dimethyl-thiazol-2-yl)-hydrazine | O-acyl oxime isatin derivative, 55 | SMR000514729 | cid_2873173
Type:
Small organic molecule
Emp. Form.:
C13H13N3O2S
Mol. Mass.:
275.326
SMILES:
Cc1nc(N=NCc2ccc3OCOc3c2)sc1C |w:4.3|
Structure:
Search PDB for entries with ligand similarity: