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Target
Large T antigen
Ligand
BDBM59039
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits
EC50
14580±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits PubChem Bioassay (2009)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM59039
Synonyms:
3-(4-chlorophenyl)sulfanyl-1-[4-(4-hydroxyphenyl)piperazin-1-yl]propan-1-one | 3-[(4-chlorophenyl)thio]-1-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-propanone | 3-[(4-chlorophenyl)thio]-1-[4-(4-hydroxyphenyl)piperazino]propan-1-one | MLS001003076 | SMR000372725 | cid_2423078
Type:
Small organic molecule
Emp. Form.:
C19H21ClN2O2S
Mol. Mass.:
376.9
SMILES:
Oc1ccc(cc1)N1CCN(CC1)C(=O)CCSc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: