Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM103869
Substrate
n/a
Meas. Tech.
FGFR-4 wild type assay at Km
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<10.00±n/a nM
Comments
extracted
Citation
 Bifulco, Jr., N; DiPietro, LV; Miduturu, CV Inhibitors of the fibroblast growth factor receptor US Patent  US9695165 Publication Date 7/4/2017 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM103869
Synonyms:
US9695165, 52
Type:
Small organic molecule
Emp. Form.:
C31H29Cl2N3O5
Mol. Mass.:
594.485
SMILES:
CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OC(C)(C)CN(C(=O)C=C)c2c1 |(5.33,1.44,;4,.67,;2.67,1.44,;1.33,.67,;1.33,-.87,;,-1.64,;-1.33,-.87,;-1.33,.67,;,1.44,;,2.98,;1.33,3.75,;1.33,5.29,;,6.06,;-1.33,5.29,;,7.6,;-1.33,8.37,;-2.67,7.6,;1.33,8.37,;2.67,7.6,;4,8.37,;4,9.91,;2.67,6.06,;4,5.29,;2.67,2.98,;4,3.75,;,-3.18,;1.33,-3.95,;1.33,-5.49,;,-6.26,;,-7.8,;-1.33,-8.57,;-2.1,-9.91,;-.56,-9.91,;-2.67,-7.8,;-2.67,-6.26,;-4,-5.49,;-4,-3.95,;-5.33,-6.26,;-5.33,-7.8,;-1.33,-5.49,;-1.33,-3.95,)|
Structure:
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