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Target
Tumor necrosis factor
Ligand
BDBM54531
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
4590±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54531
Synonyms:
2-(2-keto-4-phenyl-chromen-7-yl)oxy-N-(3-pyridyl)acetamide | 2-(2-oxidanylidene-4-phenyl-chromen-7-yl)oxy-N-pyridin-3-yl-ethanamide | 2-(2-oxo-4-phenylchromen-7-yl)oxy-N-pyridin-3-ylacetamide | 2-[(2-oxo-4-phenyl-1-benzopyran-7-yl)oxy]-N-(3-pyridinyl)acetamide | MLS001160511 | SMR000652637 | cid_17583746
Type:
Small organic molecule
Emp. Form.:
C22H16N2O4
Mol. Mass.:
372.3734
SMILES:
O=C(COc1ccc2c(cc(=O)oc2c1)-c1ccccc1)Nc1cccnc1
Structure:
Search PDB for entries with ligand similarity: