Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM41816
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
1564±1066 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM41816
Synonyms:
(NE)-N-[3-(2,4-dimethylanilino)-4-keto-1-naphthylidene]thiophene-2-sulfonamide | (NE)-N-[3-(2,4-dimethylanilino)-4-oxo-1-naphthalenylidene]-2-thiophenesulfonamide | (NE)-N-[3-(2,4-dimethylanilino)-4-oxonaphthalen-1-ylidene]thiophene-2-sulfonamide | (NE)-N-[3-[(2,4-dimethylphenyl)amino]-4-oxidanylidene-naphthalen-1-ylidene]thiophene-2-sulfonamide | MLS000549894 | N-(3-(2,4-dimethylanilino)-4-oxo-1(4H)-naphthalenylidene)-2-thiophenesulfonamide | SMR000113727 | cid_9549688
Type:
Small organic molecule
Emp. Form.:
C22H18N2O3S2
Mol. Mass.:
422.52
SMILES:
Cc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)c(C)c1 |w:9.9,t:6|
Structure:
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