Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63792
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
<160±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63792
Synonyms:
2-(2,4-Dichloro-phenylamino)-4-oxo-4-phenyl-butyric acid | 2-(2,4-dichloroanilino)-4-keto-4-phenyl-butyric acid | 2-(2,4-dichloroanilino)-4-oxo-4-phenylbutanoic acid | 2-[(2,4-dichlorophenyl)amino]-4-oxidanylidene-4-phenyl-butanoic acid | MLS000766654 | SMR000414629 | cid_3762447
Type:
Small organic molecule
Emp. Form.:
C16H13Cl2NO3
Mol. Mass.:
338.185
SMILES:
OC(=O)C(CC(=O)c1ccccc1)Nc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: