Reaction Details Report a problem with these data
Target
Inward rectifier potassium channel 2
Ligand
BDBM65863
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
30650±14818 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65863
Synonyms:
3-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-1H-indole | 3-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-1H-indole | 3-[[4-(4-fluorophenyl)piperazino]methyl]-1H-indole | 3-{[4-(4-fluorophenyl)piperazino]methyl}-1H-indole | MLS000860405 | SMR000458489 | cid_2812866
Type:
Small organic molecule
Emp. Form.:
C19H20FN3
Mol. Mass.:
309.3806
SMILES:
Fc1ccc(cc1)N1CCN(Cc2c[nH]c3ccccc23)CC1
Structure:
Search PDB for entries with ligand similarity: