Reaction Details Report a problem with these data
Target
Inward rectifier potassium channel 2
Ligand
BDBM65869
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
43145±28485 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65869
Synonyms:
(2,8-Dimethyl-quinolin-4-yl)-p-tolyl-amine | (2,8-dimethyl-4-quinolyl)-(p-tolyl)amine | 2,8-dimethyl-N-(4-methylphenyl)-4-quinolinamine | 2,8-dimethyl-N-(4-methylphenyl)quinolin-4-amine | MLS001212647 | SMR000516468 | cid_715695
Type:
Small organic molecule
Emp. Form.:
C18H18N2
Mol. Mass.:
262.3489
SMILES:
Cc1ccc(Nc2cc(C)nc3c(C)cccc23)cc1
Structure:
Search PDB for entries with ligand similarity: